EMBRYONIC stem cells have been used to treat human illness for the first time, improving the sight of two women with severe vision loss.

The controversial development could give hope to hundreds of thousands of people suffering macular degeneration – one of the most common forms of blindness in First World countries – and has been hailed a historic step by stem cell scientists.

In a US trial last year, two legally blind women reported sight improvements after receiving a small dose of embryonic stem cell transplantations in their eyes.

Both had different forms of macular degeneration, a group of diseases that affect the retina, causing loss of central vision.

After the transplant in July, the first woman, who suffers from dry age-related macular degeneration, went from being able to read 21 letters on a sight test chart to 28. The second woman, who has Stargardt’s disease, went from being unable to read any letters to reading five. While the scientists who conducted the study are cautious about the results, tests indicate that healthy cells have grown where the treatment was injected.

They said the patients had shown no negative reactions.

The study, reported in The Lancet this week, was led by Robert Lanza, the chief scientific officer at Advanced Cell Technology in the US – the stem cell company that funded the trial.

The research has taken place amid debate about whether the stem cells should be used because they are derived from five- to six-day-old human embryos.

The disease affects one in seven people over 50, the Macular Degeneration Foundation says.

IT MAY sound like a strange brew, but green tea and red light could provide a novel treatment for Alzheimer’s disease. Together, the two can destroy the rogue “plaques” that crowd the brains of people with the disease. The light makes it easier for the green-tea extract to get to work on the plaques.

Andrei Sommer at the University of Ulm in Germany, and colleagues, have previously used red light with a wavelength of 670 nanometres to transport cancer drugs into cells. The laser light pushes water out of the cells and when the laser is switched off, the cells “suck in” water and any other molecules, including drugs, from their surroundings.

Now, Sommer’s team have found that the same technique can be used to destroy the beta-amyloid plaques in Alzheimer’s. These plaques consist of abnormally folded peptides, and are thought to disrupt communication between nerve cells, leading to loss of memory and other symptoms.

The team bathed brain cells containing beta-amyloid in epigallocatechin gallate (EGCG) – a green-tea extract known to have beta-amyloid inhibiting properties – at the same time as stimulating the cells with red light. Beta-amyloid in the cells reduced by around 60 per cent. Shining the laser light alone onto cells reduced beta-amyloid by around 20 per cent (Photomedicine and Laser Surgery, DOI: 10.1089/pho.2011.3073).

It can be difficult getting drugs into the brain, but animal experiments show that the green-tea extract can penetrate the so-called blood-brain barrier when given orally together with red light. The light, which can penetrate tissue and bone, stimulates cell mitochondria to kick-start a process that increases the barrier’s permeability, says Sommer.

There is no reason why other drugs that attack beta-amyloid could not be delivered to the brain in the same way, he adds.

“This important research could form the basis of a potential treatment for Alzheimer’s, with or without complementary drug treatment,” says Mario Trelles, medical director of the Vilafortuny Medical Institute in Cambrils, Spain.

“The technique described could help to regulate and even stop the appearance of this disease,” he adds.

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A new study pinpoints the importance of certain soluble proteins, called cytokines, in Alzheimer’s disease. The study focuses on one of these cytokines, tumor necrosis factor-alpha(TNF), a very critical component of the brain’s immune system. Normally, TNF finely regulates the transmission of neural impulses within the brain. The authors hypothesized that elevated levels of TNF in Alzheimer’s disease interacy adversely with this regulation. To reduce elevated TNF, the authors gave patients an injection of an anti-TNF therapeutic called etanercept. Excess TNF-alpha has been documented in the cerebrospinal fluid of patients with Alzheimer’s.

The new study documents a dramatic and unprecedented therapeutic effect in an Alzheimer’s patient: improvement within minutes following delivery of perispinal etanercept, which is etanercept given by injection in the spine. Etanercept (trade name Enbrel) binds and inactivates excess TNF. Etanercept is FDA approved to treat a number of immune-mediated disorders and is used off label in the study.

The use of anti-TNF therapeutics as a new treatment choice for many diseases, such as rheumatoid arthritis and potentially even Alzheimer’s, was recently chosen as one of the top 10 health stories of 2007 by the Harvard Health Letter.

Similarly, the Neurotechnology Industry Organization has recently selected new treatment targets revealed by neuroimmunology (such as excess TNF) as one of the top 10 Neuroscience Trends of 2007. And the Dana Alliance for Brain Initiatives has chosen the pilot study using perispinal etanercept for Alzheimer’s for inclusion and discussion in their 2007 Progress Report on Brain Research.

The lead author of the study, Edward Tobinick M.D., is an assistant clinical professor of medicine at the University of California, Los Angeles and director of the Institute for Neurological Research, a private medical group in Los Angeles. Hyman Gross, M.D., clinical professor of neurology at the University of Southern California, was co-author.

This study is accompanied by an extensive commentary by Sue Griffin, Ph.D., director of research at the Donald W. Reynolds Institute on Aging at the University of Arkansas for Medical Sciences (UAMS) in Little Rock Arkansaw and at the Geriatric Research and Clinical Center at the VA Hospital in Little Rock, who along with Robert Mrak, M.D., chairman of pathology at University of Toledo Medical School, are editors-in-chief of the Medical Journal of Neuroinflammation.

Griffin and Mrak are pioneers in the field of neuroinflammation. Griffin published an extensive landmark study in 1989 describing the association of cytokine overexpression in the brain and Alzheimer’s disease. Her research helped pave the way for the findings of the present study. Griffin has recently been selected for membership in the Dana Alliance for Brain Initiatives, a nonprofit organization of more than 200 leading neuroscientists, including ten Nobel laureates.

“It is unprecedented that we can see cognitive and behavioral improvement in a patient with established dementia within minutes of therapeutic intervention,” said Griffin. “It is imperative that the medical and scientific communities immediately undertake to further investigate and characterize the physiologic mechanisms involved. This gives all of us in Alzheimer’s research a tremendous new clue about new avenues of research, which is so exciting and so needed in the field of Alzheimer’s. Even though this report predominantly discusses a single patient, it is of significant scientific interest because of the potential insight it may give into the processes involved in the brain dysfunction of Alzheimer’s.”

While the article discusses one patient, many other patients with mild to severe Alzheimer’s received the treatment and all have shown sustained and significently marked improvement.

The new study, entitled “Rapid cognitive improvement in Alzheimer’s disease following perispinal etanercept administration,” and the accompanying commentary, entitled “Perispinal etanercept: Potential as an Alzheimer’s therapeutic,” are available on the Web site of the Journal of Neuroinflammation (http://www.jneuroinflammation.com/content/5/1/2/abstract).

Author Hyman Gross, M.D., has no competing interests. Author Edward Tobinick, M.D. owns stock in Amgen, the manufacturer of etanercept, and has multiple issued and pending patents assigned to TACT IP LLC that describe the parenteral and perispinal use of etanercept for the treatment of Alzheimer’s disease and other neurological disorders, including, but not limited to, U.S. patents 6015557, 6177077, 6419934, 6419944, 6537549, 6982089, 7214658 and Australian patent 758523.

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to only Kill Cancer Cells

A new virus that has been specifically engineered to kill cancer cells has been found to be a medical first because of its effectiveness. The virus has been engineered by medical researchers to target only cancer cells throughout the human body.

The virus is very special because it only attacks cancerous tumours and leaves healthy tissue fully intact.  The virus has been trialled on humans but so far the trials have only been quite small (23 people have only been trialled so far).

If the research goes to plan then the treatment could give cancer therapies a real transformation.

Viruses have been used before to kill cancer but they have always been injected direct into the tumour in order to avoid killing the healthy cells. This new virus will without doubt make the treatment much much easier and possibly more effective.

The new virus has been developed by scientists who modified the vaccinia virus. The vaccinia virus is more commonly used usually as a smallpox vaccine. The new form of this virus is known as JX-594.

The research was guided & inspired by a team of scientists from the University of Ottawa in the United States.

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Previous research showed that the nasal vaccine was successful in preventing the disease in mice, and now the results of a study involving 52 adults with early type 1 diabetes has provided encouraging evidence that it could also be effective in preventing the disease humans.

Type 1 diabetes occurs when the body’s immune system attacks and kills the insulin-producing beta cells in the pancreas. The subsequent lack of insulin leads to increased blood and urine glucose, which can result in heart disease, stroke, kidney failure, blindness and premature death if left untreated, with the most common treatment being the daily injection of insulin.

Although the 52 participants in the study had early type 1 diabetes and had evidence of immunity to insulin-producing beta cells in the pancreas, they were not yet at the stage of requiring insulin injections. For the study, the participants were given either the nasal vaccine or a placebo for 12 months.

When administered through the nasal passages, the insulin vaccine stimulates the immune system present in the mucosal linings and works to desensitize the whole immune system to insulin so that the immune system’s white blood cells are prevented from attacking insulin in the beta cells.

“The results showed that the vaccine allowed the immune system to restore immune tolerance to insulin,” said Professor Len Harrison of the Walter and Eliza Hall Institute in Melbourne, Australia. “When subsequently given insulin by injection, the participants who had received the nasal insulin vaccine were found to be desensitized to insulin.”

The researchers from the Walter and Eliza Hall Institute and the Royal Melbourne Hospital say the results of the study indicate they are on the right track to finding a vaccine for type 1 diabetes and the same approach could also be adapted to other autoimmune diseases.

“The nasal vaccine approach, if shown to be successful in human type 1 diabetes, could also be tested with different vaccines for the prevention of other autoimmune diseases such as rheumatoid arthritis and multiple sclerosis,” added Professor Harrison.

The Type 1 Diabetes Prevention Trial, which was previously known as the intranasal insulin trial, INIT II), began in 2006 and is now halfway through the testing phase. Following the encouraging results of the study, hopes are high a nasal vaccine for type 1 diabetes could be available in as little as two years.

Details of the research was published in the April 2011 issue of the journal Diabetes.

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We all think eating fruits means just buying fruits, cutting it and just popping it into our mouths. It’s not as easy as you think. It’s important to know how and when to eat.

What is the correct way of eating fruits?

IT MEANS NOT EATING FRUITS AFTER YOUR MEALS! * FRUITS SHOULD BE EATEN ON AN EMPTY STOMACH.
If you eat fruit like that, it will play a major role to detoxify your system, supplying you with a great deal of energy for weight loss and other life activities.

FRUIT IS THE MOST IMPORTANT FOOD. Let’s say you eat two slices of bread and then a slice of fruit. The slice of fruit is ready to go straight through the stomach into the intestines, but it is prevented from doing so.

In the meantime the whole meal rots and ferments and turns to acid. The minute the fruit comes into contact with the food in the stomach and digestive juices, the entire mass of food begins to spoil….

So please eat your fruits on an empty stomach or before your meals! You have heard people complaining — every time I eat watermelon I burp, when I eat durian my stomach bloats up, when I eat a banana I feel like running to the toilet, etc — actually all this will not arise if you eat the fruit on an empty stomach. The fruit mixes with the putrefying other food and produces gas and hence you will bloat!

Graying hair, balding, nervous outburst, and dark circles under the eyes all these will NOT happen if you take fruits on an empty stomach.

There is no such thing as some fruits, like orange and lemon are acidic, because all fruits become alkaline in our body, according to Dr. Herbert Shelton who did research on this matter. If you have mastered the correct way of eating fruits, you have the Secret of beauty, longevity, health, energy, happiness and normal weight.

When you need to drink fruit juice – drink only fresh fruit juice, NOT from the cans. Don’t even drink juice that has been heated up. Don’t eat cooked fruits because you don’t get the nutrients at all. You only get to taste. Cooking destroys all the vitamins.

But eating a whole fruit is better than drinking the juice. If you should drink the juice, drink it mouthful by mouthful slowly, because you must let it mix with your saliva before swallowing it. You can go on a 3-day fruit fast to cleanse your body. Just eat fruits and drink fruit juice throughout the 3 days and you will be surprised when your friends tell you how radiant you look!

KIWI: Tiny but mighty. This is a good source of potassium, magnesium, vitamin E & fiber. Its vitamin C content is twice that of an orange.

APPLE: An apple a day keeps the doctor away? Although an apple has a low vitamin C content, it has antioxidants & flavonoids which enhances the activity of vitamin C thereby helping to lower the risks of colon cancer, heart attack & stroke.

STRAWBERRY: Protective Fruit. Strawberries have the highest total antioxidant power among major fruits & protect the body from cancer-causing, blood vessel-clogging free radicals.

ORANGE : Sweetest medicine. Taking 2-4 oranges a day may help keep colds away, lower cholesterol, prevent & dissolve kidney stones as well as lessens the risk of colon cancer.

WATERMELON: Coolest thirst quencher. Composed of 92% water, it is also packed with a giant dose of glutathione, which helps boost our immune system. They are also a key source of lycopene — the cancer fighting oxidant. Other nutrients found in watermelon are vitamin C & Potassium.

GUAVA & PAPAYA: Top awards for vitamin C. They are the clear winners for their high vitamin C content.. Guava is also rich in fiber, which helps prevent constipation. Papaya is rich in carotene; this is good for your eyes.

Drinking Cold water after a meal = Cancer! Can u believe this?? For those who like to drink cold water, this article is applicable to you. It is nice to have a cup of cold drink after a meal. However, the cold water will solidify the oily stuff that you have just consumed. It will slow down the digestion. Once this ‘sludge’ reacts with the acid, it will break down and be absorbed by the intestine faster than the solid food. It will line the intestine. Very soon, this will turn into fats and lead to cancer. It is best to drink hot soup or warm water after a meal.

A serious note about heart attacks HEART ATTACK PROCEDURE’: (THIS IS NOT A JOKE!) Women should know that not every heart attack symptom is going to be the left arm hurting. Be aware of intense pain in the jaw line. You may never have the first chest pain during the course of a heart attack. Nausea and intense sweating are also common symptoms. Sixty percent of people who have a heart attack while they are asleep do not wake up. Pain in the jaw can wake you from a sound sleep. Let’s be careful and be aware. The more we know the better chance we could survive.

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CANCER patients are offering themselves as human guinea pigs as researchers investigate a possible cure for cancer that was found in north Queensland rainforests.

Scientists have identified a compound in the fruit of the native blushwood shrub that appears to “liquefy and destroy cancer with no side-effects”, according to latest research.

Found deep in the remnants of a 130 million-year-old rainforest, the fruit extract may yet hold the secret antidote to Australia’s No.1 killer disease.

Victoria Gordon, of EcoBiotics, an Atherton Tableland-based company, said they hoped to go to human clinical trials later this year.

Dr Gordon said a single dose injection of the extract, known as EBC-46, had been effective in 50 critically ill dogs and about a dozen cats and horses.

“This is proving to be something exceptional,” she said.

“The tumour literally liquefies.

“There is a rapid knock-down of the tumour, it disintegrates within 24 hours and we have a rapid healing response.

“The biggest tumour we treated was the size of a Coke can in a dog, and that animal is fully healed and healthy.”

Dr Gordon said it had worked on skin cancers, such as carcinomas and melanomas, and bone cancer, and was a possible treatment for breast, colon and prostate cancer.

But she warned wannabe human guinea pigs against seeking under-the-table treatment.

She said it was “immoral, illegal, and unscientific” to seek to be administered the drug before approval, likely to take up to seven years, by the Therapeutic Goods Administration.

“We have been inundated with calls – it shows there is such a need for a breakthrough in anti-cancer treatment,” she said. “Most people understand when we explain the situation.”

Former breast cancer sufferer Mena Crew, 65, said many dying of cancer would “do anything for a miracle cure”.

“We would all like a magic cure, that would be wonderful, and I hope in my lifetime we find it,” the breast cancer support volunteer said.

She has worked with more than 200 sufferers and some victims in her role with the Cancer Council Queensland.

“I don’t want to kill the enthusiasm of all the wonderful research, but until it is proven it will do the job, we recommend they go with proven and conventional treatments,” she said.

“It is good, however, to think the secret antidote may be growing in the jungle above Cairns.” Queensland Australia.

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